C-erbB-2 immunostaining: problems with interpretation.

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C-erbB-2 immunostaining: problems with interpretation.

AIMS To assess the consistency and reproducibility of assessment of c-erbB-2 immunostaining, and to examine some of the problems relating to inter- and intraobserver variability in the documentation of positive staining; to profile the spectrum of cytoplasmic and membranous staining in a wide range of tumour types. METHODS A total of 283 neoplasms were examined for immunohistochemical express...

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Correlation between serum and un-stimulated whole saliva c-erbB-2 concentrations in women with breast cancer

Correlation between serum and un-stimulated whole saliva c-erbB-2 concentrations in women with breast cancer   Dr. Agha-Hosseini F.,1 Dr. Mirzai-Dizgah E.,2 Dr. Rahimi A.3 1Professor, Department of Oral Medicine. Dental Research Center, School of Dentistry, Medical Sciences / University of Tehran, Tehran, Iran. 2Assistant professor, Department of Physiology, School of Medicine, Army University ...

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c-erbB-3

c-erbB receptors are usually located in cell membranes and are activated by extracellular binding of EGF-like growth factors. Unexpectedly, using immunofluorescence we found high levels of c-erbB-3 within the nuclei of MTSV1-7 immortalized nonmalignant human mammary epithelial cells. Nuclear localization was mediated by the COOH terminus of c-erbB-3, and a nuclear localization signal was identi...

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Amplification of c-erbB-2 and aggressive human breast tumors?

well as allelic deletions ofgenes on chromosomes 11 or 13 (9, 10). The frequency and level of amplification of c-myc and c-erbB-2 proto-oncogenes vary between different groups of patients studied by different laboratories. Amplification of c-erbB-2 was reported in 10, 16, 18, and 40% of breast tumors from different groups of patients (2, 5-8). In one study this proto-oncogene was suggested as a...

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Expression of MIF and c-erbB-2 in endometrial cancer

The aim of the present study was to investigate the expression of c-erbB-2 and macrophage migration inhibitory factor (MIF) in endometrial cancer and to elucidate the significance of the early diagnosis and prognosis of endometrial cancer. The gene copy number of c‑erbB‑2 and MIF was characterized by reverse transcription quantitative polymerase chain reaction and the reactivity was assessed by...

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 1994

ISSN: 0021-9746

DOI: 10.1136/jcp.47.9.816